Niacinamide 90c by Pure Encapsulations is a precursor of nicotinamide adeninedinucleotide (NAD), essential for oxidation-reduction reactions, nutrient metabolism and ATP synthesis. It does not cause the vasodilatation (“flush”) associated with niacin. Research indicates that niacinamide may support healthy glucose metabolism and protect pancreatic beta cell function. In a meta-analysis of 10 randomized controlled trials, niacinamide supplementation promoted healthy C-peptide levels, insulin metabolism and beta cell function. In another study, niacinamide helped maintain healthy C-peptide levels, HbA1c and glucose metabolism. Niacinamide also promotes joint mobility and comfort. In a 12-week randomized double-blind trial involving 72 subjects, niacinamide provided statistically significant support for joint flexibility and normal inflammatory response. Alpha lipoic acid is included to offer synergistic support for healthy glucose balance and metabolic function.