Description:
Genova Diagnostics NeuroGenomic Profile evaluates single nucleotide polymorphisms (SNPs) in genes that modulate methylation, glutathione conjugation, oxidative protection and the potential to evaluate vascular oxidation. Requires a blood draw. Small fee required to draw blood at lab of your choice. No doctors order required.NOT AVAILABLE IN NEW YORK.

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The test uncovers potential genetic susceptibility to:

• ·Neurodegenerative Disorders

•  Developmental Issues
•  Mood Disorders
• Oxidative Stress
•  Detoxification Capacity
• Methylation
•  MTHFR (methylenetetrahydrofolate reductase)
•  COMT (catechol-O-methyltransferase)

These genes affect how homocysteine and methionine are metabolized to support formation
of S-adenosylmethionine (SAMe). The ability to donate methyl groups affects neurologic
function and is modifiable by proper B-vitamin intake.
Detoxification
· GSTM (glutathione-s-transferase, M, isoforum)

· GSTP (glutathione-s-transferase, P, isoforum)

These genes are responsible for detoxifying products of oxidative stress and carcinogens.
Variants decrease detoxification capacity.
Oxidative Protection
· SOD-2 (Superoxide dismutase -2)

These genetic variants alter anti-oxidant enzyme activity and modify requirements for antioxidants.

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