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DetoxiGenomic Profile by Genova Diagnostics

DetoxiGenomic Profile by Genova diagnostics test evaluates SNPs associated with increased risk of impaired detoxification capacity especially when exposed to environmental toxins. It also identifies individuals potentially susceptible to adverse drug reactions.

Not available to NY residents.

  • Purchase on our secure website.
  • Lab order is provided by us.
  • You receive a collection kit for saliva, urine, or finger stick to collect at home and mail to the lab. Some tests require a blood draw at a local lab.
  • You receive the results by email within 2-3 weeks.


Patient Name

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Date of Birth

The patient's Date of Birth is required for all test kit purchases


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Phase I: Cytochrome P-450
• CYP1A1 • CYP2A6 • CYP2E1 • CYP1C19
• CYP1B1 • CYP2D6 • CYP2C9 • CYP3A4
Phase I is the first line of defense in the detoxification of all environmental toxins, including
pesticides, herbicides, pollutants, and solvents, pharmaceuticals and nutraceuticals, as well as
many of the body’s own waste products (including steroid hormones).
Phase II: Conjugation of Toxins and Elimination
Methylation (catechol-O-methyltransferase)
Polymorphisms may lead to impaired metabolism of the catecholamine neurotransmitters
(dopamine, epinephrine, and norepinephrine) and may predispose individuals to anxiety,
ADHD, alcoholism, and rapid cycling in bipolar individuals.
Acetylation (N-acetyl transferase)
• NAT1 • NAT2
NAT detoxifies many environmental toxins, including tobacco smoke and exhaust fumes.
Polymorphisms may result in slow or rapid acetylation, both associated with increased risk of
lung, colon, bladder, or head & neck cancer.
Glutathione Conjugation (glutathione s-transferase)
GST detoxifies many water-soluble environmental toxins, including solvents, herbicides,
fungicides, and heavy metals (eg, mercury, cadmium, and lead). Defects in GST activity can
contribute to fatigue syndromes and many cancers.
Oxidative Protection (superoxide dismutase)
• SOD1 • SOD2
Mutations affecting these antioxidant enzymes can lead to increased free radical activity and
cell damage, and may increase the risk of developing neurodegenerative disorders.

ANALYTE LIST: COMT V158M CYP 1B1 N453S CYP 1B1 V432L CYP 2A6*2 L160H CYP 2C19*2 2C192 CYP 2C19*3 2C193 CYP 2C9*2 R144C CYP 2C9*3 I135L CYP 2D6*3 A2637 CYP 2E1*5A P2E15 CYP 3A4*17 R162Q CYP 3A4*1B 290AG CYP 3A4*3 M445T CYP1A1*2A MSPI
CYP1A1*2C I462V GSTM1 NAT 1 R187Q NAT 1 R64W NAT 2 G286E NAT 2 I114T NAT 2 K268R NAT 2 R197Q NAT 2 R64Q

SOD 1 G93A SOD 2 A16V
GSTP1, A104V and A113V
Adrenocortex Stress Profile (ASP)
Bacteriology, aerobic
Turn Around Time: 21 Days




Genova Diagnostics

We are proud to offer testing from Genova Diagnostics. They provide functional lab testing that focuses on finding the cause of your problems, not just treating the symptoms. Many of these tests focus prevention by arming you with the knowledge of what lifestyle changes you need to make in order to stop or slow the progression of heart disease, diabetes, auto immune disease and many more. Genova Labs has now merged with Metametrix, so you get two great labs in one! How does this work? 1. Purchase online. 2. Lab order provided by us. 3. Collect saliva, urine or fingerstick at home and mail to the lab. Some tests require blood draw at a lab of your choosing. 4. You receive the results by email within 2-3 weeks. 5. Practitioner phone consultations available, some included with test. Not available in MD. Some tests not available in NY. How do I know what test I need? 1. If you are already working with a practitioner, ask them. 2. Get recommendations from our wellness practitioners with a phone consultation. 3. Check out our Genova Test Selection Guide.
Genova Diagnostics
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