Several controlled clinical trials attest to the safety and effectiveness of standardized butterbur extract (Eur Neurol 2004;51:89-97; Neurology 2004;63:2240-4; Inter J Clin Pharmacol Ther 2000;38:430-435).
Butterbur products guaranteed free of undesirable pyrrolizidine alkaloids are the preferred form of this remedy (Praxis-Telegram Nr. 1/98:13-14).
Magnesium participates in the regulation of vascular tone and reactivity by influencing platelet function, acting as a mild calcium channel blocker, and regulating the effects of serotonin and other neurotransmitters (Persp Biol Med 1988;31:526-7).
Magnesium supplementation helps increase days without head discomfort according to several controlled clinical studies (Headache 1991;31:298-301; Fortschr Med 1994;112:328-330; Cephalalgia 1996;16:257-263).
Riboflavin, which may help correct certrain mitochondrial dysfunctions related to head discomfort, has also been effective in a controlled clinical study (Neurology 1998;50:466-70).
SERVING SIZE: 3 Vegetable Capsules
SERVINGS PER CONTAINER: 30
AMOUNT PER SERVING:
Vitamin B-2 (riboflavin) 200 mg
Magnesium (aspartate) 600 mg
Butterbur (Petasites hybridus) 150 mg
Vegetarian capsule, vegetable stearate.
Take 1 capsule, with meals, three times daily, or as directed. Limit to 1 capsuel per day for every 50 pounds of body weight.