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ImmunoGenomic Profile Buccal Rinse

ImmunoGenomic Profile evaluates genetic variations, called single nucleotide polymorphisms (SNPs), in genes that modulate immune and inflammatory activity. Polymorphisms affect the levels and activity of the cytokines. These variations can affect balance between cell-mediated (TH-1) and humoral (TH-2) immunity, reveal potential defects in immune system defense, and stimulate mechanisms leading to chronic, overactive inflammatory responses. NOT AVAILABLE IN NEW YORK.

  • Purchase on our secure website.
  • Lab order is provided by us.
  • You receive a collection kit for saliva, urine, or finger stick to collect at home and mail to the lab. Some tests require a blood draw at a local lab.
  • You receive the results by email within 2-3 weeks.
  • Got insurance? Some tests are covered. Call 800 385-7863 for more information.


Patient Name

The patient's name is required for all test kit purchases

Date of Birth

The patient's Date of Birth is required for all test kit purchases


Add-ons total:



The test uncovers potential genetic susceptibility to:
• Asthma • Autoimmune Disorders
• Certain Cancers • Allergy
• Infectious Diseases • Bone Inflammation
• Arthritis • Inflammatory Bowel Disease
• Heart Disease • Osteopenia
• Helicobacter pylori infection (cause of ulcers)
Chronic Inflammation
• IL-1ß (interleukin-1beta)
This gene affects the duration and intensity of the acute inflammatory response. The
polymorphism leads to increased production of IL-1B, hypochlorhydria, increased
susceptibility to H. pylori infection, and gastritis and gastric cancer in H. pylori-infected
TH-1 Cytokines (Viral Infection & Cancer)
• TNF-α (tumor necrosis factor-alpha)
Polymorphisms of this gene affect cell-mediated immunity, increasing production of the proinflammatory
cytokine TNF-alpha. This can promote or exacerbate chronic conditions such as
arthritis, osteoporosis, and asthma.
TH-2 Cytokines (Allergy, Asthma, and Atopy)
• IL-4 (interleukin-4) • IL-6 (interleukin-6)
• IL-10 (interleukin-10) • IL-13 (interleukin-13)
TH-2 cytokines promote humoral immunity, including the synthesis of IgE. They are generally
regarded as anti-inflammatory; however, excessive activity of some of these cytokines may
promote the development of allergic conditions such as atopy, asthma, and hypersensitivity.
Low levels may result in chronic inflammatory conditions characterized by a TH-1 response.
IL-6 has both pro- and anti-inflammatory properties; this cytokine drives the acute phase
response and can promote chronic inflammation and progression in autoimmune disease.

Specimen Requirements:

Buccal–Two morning collections of mouthwash rinse (20 ml)


Blood–One 9 ml blood sample in EDTA tube

Blood–One 9 ml blood sample in EDTA tube


Genova Diagnostics

We are proud to offer testing from Genova Diagnostics. They provide functional lab testing that focuses on finding the cause of your problems not just treating the symptoms. Many of these test focus prevention by arming you with the knowledge of what lifestyle changes you need to make in order to stop or slow the progression of heart disease, diabetes, auto immune disease and many more. Genova Labs has now merged with Metametrix so you get two great labs in one! How does this work? 1. Purchase online 2. Lab order provided by us. 3. Collect saliva, urine, or fingerstick at home and mail to the lab. Some tests require blood draw at a lab of your choosing. 4. You receive the results by email within 2-3 weeks. 5. Practitioner phone consultations available, some included with test. Not available in MD. Some tests not available in NY. How do I know what test I need? 1. If you are already working with a practitioner ask them. 2. Get recommendations from our wellness practitioners with a phone consultation. 3. Check out our Genova Test Selection Guide
Genova Diagnostics


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