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Estrogen Metabolism Plus by Genova Diagnostics

Metabolism Plus is a comprehensive urinary estrogen metabolism evaluation designed to assist in the prevention and treatment of estrogen-related symptoms and conditions. This provides clues about menstrual irregularities, infertility, endometriosis, breast cancer, prostate cancer, and osteoporosis.

  • Purchase on our secure website.
  • Lab order is provided by us.
  • You receive a collection kit for saliva, urine, or finger stick to collect at home and mail to the lab. Some tests require a blood draw at a local lab.
  • You receive the results by email within 2-3 weeks.


Patient Name

The patient's name is required for all test kit purchases

Date of Birth

The patient's Date of Birth is required for all test kit purchases


Add-ons total:



Estrogen Metabolism Plus is ideal for:
• The prevention and treatment of hormone-related symptoms and conditions
• Prescribing and monitoring Hormone Replacement Therapy (HRT)
• Assessing the risk of hormone-related disease, including breast cancer

Analytes tested:

2:16 Ratio
2-Methoxyestrone:2-Hydroxyestrone Ratio
4-Methoxyestrone:4-Hydroxyestrone Ratio

The Benefits of Urine Hormone Testing:

First-Morning-Void OR 24-hour urine collection
These simple, at-home collection options offer the advantage of a time average, effectively
integrating spikes that may occur in these hormones over time.
Measures the free, bio-available fraction of hormones
Urinary testing measures the portion of hormones that are active in the body.
Measures the metabolites of these important steroid hormones
These metabolites contribute to provide a robust analysis of hormonal excess or deficiency,
and help to assess the adequacy and safety of hormone replacement therapy (HRT).
Anabolic/Catabolic Balance (ACB)
The ACB evaluates the ability for “growth and healing” (anabolic) versus the state of
“wear and tear” (catabolic).
Methylation Capacity
Methylation is required for effectively eliminating carcinogenic hormone metabolites,
and for activating protective hormones against cancer.

Therapy is directed at the source of the abnormality, which may include:
• HRT – estrogen, progesterone, androgens, thyroid, cortisol, etc.
• Estrogen Metabolism support – Indole-3-carbinol (I3C) and/or Diindolemethane (DIM)

Before Taking this Test:
Premenopausal women, note date of menstrual cycle on the requisition.

Recommend women on HRT or hormonal contraceptives, to obtain specimen approximately
8-10 hours AFTER the last dose.


Genova Diagnostics

We are proud to offer testing from Genova Diagnostics. They provide functional lab testing that focuses on finding the cause of your problems, not just treating the symptoms. Many of these tests focus prevention by arming you with the knowledge of what lifestyle changes you need to make in order to stop or slow the progression of heart disease, diabetes, auto immune disease and many more. Genova Labs has now merged with Metametrix, so you get two great labs in one! How does this work? 1. Purchase online. 2. Lab order provided by us. 3. Collect saliva, urine or fingerstick at home and mail to the lab. Some tests require blood draw at a lab of your choosing. 4. You receive the results by email within 2-3 weeks. 5. Practitioner phone consultations available, some included with test. Not available in MD. Some tests not available in NY. How do I know what test I need? 1. If you are already working with a practitioner, ask them. 2. Get recommendations from our wellness practitioners with a phone consultation. 3. Check out our Genova Test Selection Guide.
Genova Diagnostics


Health Remedies has merged with its sister site, Integrative Psychiatry, in order to better serve you.

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