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Estrogen Metabolism Assessment, Urine

This test assesses hydroxyestrogens in urine, providing a rapid, convenient way to evaluate clinical interventions (including hormone therapy, diet, and lifestyle changes) aimed at optimizing estrogen metabolism. Estrogen metabolites provide valuable clinical information regarding cancer risk. Not Available to New York Residents.

  • Purchase on our secure website.
  • Lab order is provided by us.
  • You receive a collection kit for saliva, urine, or finger stick to collect at home and mail to the lab. Some tests require a blood draw at a local lab.
  • You receive the results by email within 2-3 weeks.


Patient Name

The patient's name is required for all test kit purchases

Date of Birth

The patient's Date of Birth is required for all test kit purchases


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The potential impact of estrogen on a person’s health and well-being is enormous.

Estrogen can exert a strong influence in diverse conditions such as:
• Breast cancer
• Prostate cancer
• Osteoporosis
• Heart disease
• Autoimmune disorders
Recent scientific advances into estrogen metabolism have shed new light on more
effective clinical interventions in estrogen-dependent conditions.

Estrogen Metabolism

Estrogen metabolites provide valuable clinical information regarding cancer risk. Two
significant metabolites that can be accurately assessed are 16 alpha-hydroxyestrone
(16 alpha-OHE1) and 2-hydroxyestrone (2-OHE1).
• 16 alpha-OHE1 is a powerful metabolite that stimulates target tissues. Levels can rise in
response to obesity, alcohol consumption, and toxic exposure. High levels of this potent
metabolite are linked to increased risk and poorer prognosis in conditions linked to
estrogen excess such as breast cancer and lupus.
• 2-OHE1 is a metabolite that binds weakly to cell receptors and may slow cell proliferation.
Excessive levels of 2-OHE1 may increase the risk of osteoporosis in post-menopausal
women with low estrogen.
The ratio between 2-OHE1 and 16 alpha-OHE1 is the key to optimizing health.
Treatments that increase the 2:16 alpha-OHE1 ratio help to reduce the risk of estrogendependent
disease. Using this assessment, practitioners canmonitor the impact of dietary
intervention (flaxseed, soy products, cruciferous vegetables or derivatives like indole-3-carbinol
and diindolylmethane, omega-3 fatty acids) and exercise. The ratio also allows for accurate
monitoring of clinical safety and effectiveness of hormone replacement therapy (HRT).
The Estrogen Metabolism Assessment is designed for both premenopausal and
postmenopausal women. It can be performed using serum or urine. Serum sampling
provides a direct assessment of circulating estrogen metabolites. Urine testing offers
convenient, noninvasive sample collection.


Genova Diagnostics

We are proud to offer testing from Genova Diagnostics. They provide functional lab testing that focuses on finding the cause of your problems not just treating the symptoms. Many of these test focus prevention by arming you with the knowledge of what lifestyle changes you need to make in order to stop or slow the progression of heart disease, diabetes, auto immune disease and many more. Genova Labs has now merged with Metametrix so you get two great labs in one! How does this work? 1. Purchase online 2. Lab order provided by us. 3. Collect saliva, urine, or fingerstick at home and mail to the lab. Some tests require blood draw at a lab of your choosing. 4. You receive the results by email within 2-3 weeks. 5. Practitioner phone consultations available, some included with test. Not available in MD. Some tests not available in NY. How do I know what test I need? 1. If you are already working with a practitioner ask them. 2. Get recommendations from our wellness practitioners with a phone consultation. 3. Check out our Genova Test Selection Guide
Genova Diagnostics


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