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Cyrex Alzheimer’s LINXTM Alzheimer’s-Associated Immune Reactivity Test

The results from your Alzheimer’s LINX™ test provide personalized information regarding environmental and physiological risk factors that may play a role in the development of Alzheimer’s disease.

Alzheimer’s LINX™ is the most comprehensive and advanced risk assessment test for cognitive decline. It is performed by ELISA [Enzyme-Linked Immunosorbent Assay], the most reliable lab technology for antibody testing. Click here to learn more.

cyrex alzheimers linx


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Clinical Use

To identify patients at greater risk for developing Alzheimer’s disease or other neurological disorder.

To identify reactivity to triggers of Alzheimer’s disease or other neurological disorder.

To identify the early stage of neurodegenerative processes.

To monitor the effectiveness of lifestyle modifications for Alzheimer’s disease.

Recommended for patients who:

  • Are interested in preventing the development of Alzheimer’s disease or other neurological disorder.
  • Are exhibiting early signs of Alzheimer’s disease or other neurological disorder.
  • Have been diagnosed with Alzheimer’s disease.
  • Have a history of gastrointestinal disorders and/or diabetes.
  • Played high-impact sports.
  • Are immunoreactive against specific pathogens, chemicals and foods.

Antigens Tested
Brain Proteins
Tau Protein IgG
Amyloid-Beta Peptide IgG
Rabaptin-5 + Presenilin IgG
Alpha-Synuclein IgG

Growth Factors
Beta Nerve Growth Factor IgG
Brain Derived Neurotrophic Factor IgG
Neurotrophins IgG
Somatotropin IgG

Enteric Nerve, Enzymes and Neurological Peptides
Enteric Nerve + Vasoactive Intestinal Peptide IgG
Transglutaminases IgG

Oral Pathogens IgG
Enterococcus faecalis IgG
Escherichia coli CDT + Salmonella CDT IgG
Campylobacter jejuni CDT IgG
Herpes Type-1 IgG

Aluminums IgG
Dinitrophenyl IgG
Ethyl + Methyl Mercury IgG
Phthalates IgG

Foods Cross-Reactive to Amyloid-Beta
Egg Yolk, raw + cooked IgG
Lentil Lectin + Pea Lectin IgG
Tuna, canned IgG
Hazelnut Vicilin + Cashew Vicilin IgG
Scallops + Squid IgG
Caseins IgG
Alpha-Gliadin + Gliadin Toxic Peptide IgG
Non-Gluten Wheat Proteins IgG

Blood-Brain Barrier and Neurofilaments
Blood-Brain Barrier Protein + Claudin-5 IgG
Aquaporins IgG
Neurofilaments Proteins IgG

Alzheimer’s LINXTM — Alzheimer’s-Associated Immune Reactivity


Cyrex Labs

Cyrex Labs is an advanced clinical laboratory focusing on mucosal, cellular and humoral immunology and specializing in antibody arrays for complex thyroid, gluten and other food-associated autoimmunities and related neurodysregulation. Cyrex’s Scientific Advisory Board, comprised of experts from a variety of medical and research disciplines, brings together the latest findings from medical research and the assessment needs of today’s healthcare professionals. Out of this collaboration, Cyrex develops the next generation of clinical lab testing that is required to care for present-day complex maladies.

Cyrex adheres to and surpasses the highest standards of clinical laboratory testing worldwide. A Cyrex-designed quality control criterion called The Double Assurance System (QC2™) is the standard operating procedure at Cyrex Laboratories. In fact, Cyrex’s proprietary QC2™ method enhances the reproducibility, specificity and sensitivity of all Cyrex arrays. Only Cyrex tests contain the accuracy enhancements provided by The Double Assurance System.

Before ordering please consider the following: • Patient has been clear of immunosuppressant AND/OR corticosteroid drugs for at least 60 days. • Patient has had timely and adequate antigen exposure in order to measure antibody responses.

Q: Are there any medications, foods, conditions or other factors that could interfere with the results of a Cyrex test?

A: Yes. While Cyrex is unable to provide an exhaustive answer to this question due to the interactive complexities and varieties of medications and patient circumstances, the following has been noted:

a. Immunosuppressant and corticosteroid drugs can reduce antibody production and cause false negative results. b. Limited assessments on the effects of aspirin, acetaminophen, and antipsychotics on Arrays 1-4 have been performed. No noticeable effects were observed. c. Inhalers can affect the results of Cyrex's oral fluid testing (Array 1). Wait two weeks after completion of inhalant dosages before collecting the specimen. d. Unknown cross-reactive epitopes from foods and microorganisms may stimulate the antibody production in the absence of a true antigen. Cyrex has already developed Array 4 in order to recognize the most common antigens in this regard. e. A gluten-free diet can cause false negative results on gluten protein/peptide tests. f. Certain conditions, such as ileal pouch surgery, may cause a false positive celiac serology.1

1. Lian L, Remzi FH, Kiran RP, Fazio VW, Shen B. Clinical implication of false-positive celiac serology in patients with ileal pouch. Dis Colon Rectum. 2010 Oct; 53(10):1446-1451.
Cyrex Labs
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