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Essential Estrogens Urine Hormone test

BrandGenova Diagnostics

Essential Estrogens provides a focused overview of estrogen balance in both pre- and post-menopausal women, using a single urine sample to evaluate dynamics of sex steroid metabolism that can profoundly affect a woman's health throughout her lifetime.Designed to assist in the prevention and treatment of estrogen-related symptoms and conditions. Simple urine collection you do at home and mail to the lab. NOT AVAILABLE TO NEW YORK RESIDENTS.

  • Purchase on our secure website.
  • Lab order is provided by us.
  • You receive a collection kit for saliva, urine, or finger stick to collect at home and mail to the lab. Some tests require a blood draw at a local lab.
  • You receive the results by email within 2-3 weeks.
  • Got insurance? Some tests are covered. Call 800 385-7863 for more information.
  • Practitioner phone consultations available, some included with test.

This profile measures the following urinary estrogens and estrogen metabolites, and includes an assessment of estrogen methylation, which is a critical step in the protective mechanism of estrogen metabolism.



2:16 Ratio
2-Methoxyestrone:2-Hydroxyestrone Ratio

Estrogens, particularly estrone and estradiol, are well described in the literature regarding the health and disease of estrogen sensitive tissues.

Estrogen deficiency

Menopausal symptoms

Estrogen excess

Uterine fibroids
Breast Cancer

Estrogen metabolites are proven to convey protection (if balanced) or increased risk (if imbalanced) for disease.

Estrogen metabolite imbalance results in increased risk of:

Breast cancer
Prostate cancer

Estrogen methylation is a critical step in the protective mechanism of estrogen metabolism. Methylation is required for the protective effects of 2-hydroxy-estrone, and for the safe detoxification of 4-hydroxy-estrone.


Therapy is directed at the source of the abnormality, which may include treatments such as ERT in estrogen deficiency, S-adenosyl-methionine (SAMe) to improve estrogen methylation, and Indole-3-carbinol (I3C) and/or Di-indolemethane (DIM) for balancing estrogen metabolites.

About the Manufacturer

Genova Diagnostics and Metametrix have merged.

Genova Diagnostics is a global leader in functional laboratory testing, pioneering innovative new approaches to personalized medicine.

These tests focus on wellness, and prevention and allow you to take an active role in managing your health.Functional testing is designed to help identify problems before chronic conditions and diseases develop. Unlike traditional labs that focus on disease pathology, Genova and Metametrix specializes in comprehensive panels that combine standard and innovative biomarkers to provide a more complete understanding of specific biological systems. Insurance billing for these tests requires a phone consult with one of our practitioners to determine which test is right for you and to assign the code required by your insurance company.

Want to find the cause of your symptoms?

1. Purchase your labtest online.

2. The Lab order is provided by us.

3. Collect your saliva, urine, or fingerstick at home and mail to the lab. Some tests require blood draw at a lab of your choosing.

4. You receive the results by email within 2-3 weeks.

5. Practitioner phone consultations available, some included with test.

Not available in MD. Some tests not available in NY.

How do I know what test I need?

1. If you are already working with a practitioner ask them.

2. Call our office to schedule a phone consultation and get recommendations from our wellness practitioners.

3. Use our Genova-Metametrix test selection guide.

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