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The Many Health Benefits of Resveratrol

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Resveratrol is a naturally occurring plant polyphenol found in grapes.  It is the principle biologically active component found in red wine.  Research studies in humans have shown that resveratrol possesses powerful anti-oxidant and anti-inflammatory properties that can protect your heart, brain, and eyes.  It has even been shown to display anti-aging effects. Reseratrol accomplishes all this because it activates proteins called sirtuins.  Sirtuins exhibit the same anti-aging effects as calorie restriction. 

Initial interest in resveratrol started with the observation that despite consuming diets high in saturated fat, French populations enjoy a low incidence of heart disease.  This, by now well-known “French Paradox”, ultimately led to the discovery that red wine, which contains significant concentrations of resveratrol, confers many health benefits.  Since that discovery, much research has further uncovered the biological effects of resveratrol, showing its potential benefits in slowing down age-related heart, brain, and eye disorders.

Food sources other than red wine that contain appreciable amounts of resveratrol include mulberries, blueberries, raspberries, the skin of red grapes, and peanuts.

In addition to activating sirtuins, resveratrol may exert its health benefits across different diseases via distinct mechanisms. 

Some of these include: 

  • Inhibits tumor growth, cancer cell migration, invasion, and metastasis
  • Limits DNA damage caused by inflammation
  • Guards against blood clots
  • Reduces oxidative stress
  • Enhances the survival of brain cells

Regardless  of the exact mechanisms, resveratrol is one of those supplements I try to take daily (in the form of RememorAll) and one that I prescribe for all my patients interested in protecting their brains and bodies against the ravages of aging. 

In addition to resveratrol, I take numerous other supplements designed to slow down the rate at which my brain cells age:  probiotics, fish oil, vitamin D3, PEA, organic lithium orotate, NAC, methylated folate, vitamin B12, mitochondrial support, and targeted amino acid therapy (5-HTP, tyrosine) to support healthy levels of serotonin, dopamine, and GABA.

To minimize the number of pills, I take combination products such as these: 

Of course, everybody is unique.  No one size fits all.  As such, there is no substitute for a thorough clinical evaluation and testing of your neurotransmitters, adrenal function, hormones (thyroid and reproductive), and immune function.  But these core supplements are a good start. 

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