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Like any parent, you desire to give your child the best life possible. However, as a parent of a child with autism, you face many unique challenges in achieving that goal.
One of those challenges is determining which of the many therapeutic options available will work best for your child.
Based on these mechanisms of infections, toxic chemicals, and dietary peptides induction of neuroimmunological disorders, the following groups of lab tests are recommended:
Involvements of different systems in autism
Similar to many complex diseases, genetic and environmental factors including infections, xenobiotics, dietary proteins and pep-tides, play a critical role in the development of autism. The effects of environmental factors on genetic makeup result in immune, gastrointestinal, neurological, biochemical and neuroimmunological abnormalities.
The role of infectious agents in autism
Many infectious agents, including Streptococcus, measles, Rubella, Cytomegalo virus, Varicella zoster, Herpes type-6 and others have long been suspected as etiologic factors in autism. Maternal or post-maternal exposure to these infectious agents may result in neurological disorders including autism.
The role of heavy metals and other toxic chemicals in autism.
Xenobiotics have been suspected to contribute to the induction of autoimmunity. Many environmental chemicals or drugs are toxic to hosts, and their detoxification is achieved primarily in the liver. During their metabolism, they may form reactive metabolites, which can then modify cellular proteins to form neo antigens. The precise mechanisms that lead to modification of self-proteins and the molecular requirements for this modified self to induce tolerance breakdown remain to be established.
Immune reactions to drugs or their metabolites can develop when a hapten carrier complex inter-acts with gut-associated lymphoid tissues (GALT) that constitute the largest lymphoid organ. If covalent adducts of drugs or other chemical compounds are formed in GALT, it seems reasonable that they may lead to immune responses and chemically-induced Type I- Type IV allergic reactions.
Binding of dietary peptides to different tissue enzymes may promote development of peptidase antibodies in children with autism.
Opioid peptides are available from a variety of food sources. These dietary proteins and peptides, including casein, casomorphins, gluten (GLU) and gluteomorphins, can stimulate T-cells, induce peptide-specific T-cell responses, and abnormal levels of cytokine production, which may result in inflammation, autoimmune reactions and disruption of neuroimmune communications.
A majority of children with autism can not tolerate wheat and milk proteins or peptides and hence elimination of these peptides from the diets significantly improves their conditions. We detected IgG, IgM and IgA antibodies against nine specific neuron-specific antigens in the sera of children with autism. These antibodies were found to bind with different encephalitogenic molecules that have sequence homologies to a milk protein.
Not available in NY or MD.