Description:
Urinary polypeptides have been measured and correlated with medical problems for the past 50 years, including a clinical relationship with behavioral problems such as autism, ADD/ADHD, schizophrenia, and depression. Total urinary peptides are globally associated with an increase in neurologic and psychiatric imbalance. Urine test you collect at home and send to the lab. Doctors order provided, you receive the results. There are four basic types of urinary polypeptides measured: - Indolyl-acryloylglycine (IAG) - a metabolic byproduct of tryptophan. - Serotonin uptake stimulators - peptides that decrease serotoninergic energy. - Hyperkinese peptides - recently discovered urinary peptides associated with ADHD. - Exogenous morphinelike compounds - opioid peptides derived from food.

The Effect of Intestinal Permeability:

Polypeptides circulating in the bloodstream are found in the urine of children (and adults)
with neuro-psychiatric problems. This can be a consequence of increased intestinal
permeability, sometimes referred to as “leaky gut”.

Increased intestinal permeability increases passage of peptides due to:

• Infection

• Dysbiosis

• Parasites

• Yeast overgrowth

• Food allergies

• Nutritional deficiencies causing damage to the intestinal lining

Foods and Autism

Parents have observed that certain foods appear to exacerbate symptoms of autism. It has been determined that symptoms particularly arise from proteins, including gluten (from wheat and other cereals) and casein (derived from milk). Some of the peptides obtained from gluten and casein are very similar to endorphins found in the brain.

Treatment options involve diet, supplementation and eradication of intestinal irritants. Recognizing the presence of these urinary polypeptides determines the therapeutic recommendations for healing the gastrointestinal tract. The use of dietary and gastrointestinal interventions must be seen as part of an overall treatment plan.

Increased levels in peptides in the urine and serum are associated with increased rates of autism, schizophrenia, and some forms of despression.
They are derived from:
- Gluten (wheat)
- Gliadin
- Casein (milk)