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This profile measures the following urinary estrogens and estrogen metabolites, and includes an assessment of estrogen methylation, which is a critical step in the protective mechanism of estrogen metabolism.

Interpretation Estrogens, particularly estrone and estradiol, are well described in the literature regarding the health and disease of estrogen sensitive tissues.
Estrogen deficiency • Osteoporosis • Amenorrhea • Menopausal symptoms
Estrogen excess • Menorrhagia • Uterine fibroids • Anxiety/irritability • Breast Cancer
Estrogen metabolites are proven to convey protection (if balanced) or increased risk (if imbalanced) for disease.
Estrogen metabolite imbalance results in increased risk of: • Breast cancer • Osteoporosis • Prostate cancer
Estrogen methylation is a critical step in the protective mechanism of estrogen metabolism. Methylation is required for the protective effects of 2-hydroxy-estrone, and for the safe detoxification of 4-hydroxy-estrone.
Treatment Therapy is directed at the source of the abnormality, which may include treatments such as ERT in estrogen deficiency, S-adenosyl-methionine (SAMe) to improve estrogen methylation, and Indole-3-carbinol (I3C) and/or Di-indolemethane (DIM) for balancing estrogen metabolites. |